Selected Publications
For a full list of publications, see our Google Scholar page.
Approximating Projections of Conformational Boltzmann Distributions with AlphaFold2 Predictions: Opportunities and Limitations
Benjamin P. Brown*, Richard A. Stein, Jens Meiler*, Hassane S. Mchaourab*
Journal of Chemical Theory and Computation
2024
Allele-specific activation, enzyme kinetics, and inhibitor sensitivities of EGFR exon 19 deletion mutations in lung cancer
Benjamin P. Brown*, Yun-Kai Zhang, Soyeon Kim, Patrick Finneran, Yingjun Yan, Zhenfang Du, Jiyoon Kim, Abigail Leigh Hartzler, Michele L. LeNoue-Newton, Adam W. Smith*, Jens Meiler*, Christine M. Lovly*
Proceedings of the National Academy of Sciences of the United States of America
2022
Co-occurring gain-of-function mutations in HER2 and HER3 modulate HER2/HER3 activation, oncogenesis, and HER2 inhibitor sensitivity
Ariella B Hanker*, Benjamin P. Brown, Jens Meiler, Arnaldo Marín, Harikrishna S Jayanthan, Dan Ye, Chang-Ching Lin, Hiroaki Akamatsu, Kyung-Min Lee, Sumanta Chatterjee, Dhivya R Sudhan, Alberto Servetto, Monica Red Brewer, James P Koch, Jonathan H Sheehan, Jie He, Alshad S Lalani, Carlos L Arteaga*
Cancer Cell
2021
Structure–function analysis of oncogenic EGFR Kinase Domain Duplication reveals insights into activation and a potential approach for therapeutic targeting
Zhenfang Du, Benjamin P. Brown, Soyeon Kim, Donna Ferguson, Dean C Pavlick, Gowtham Jayakumaran, Ryma Benayed, Jean-Nicolas Gallant, Yun-Kai Zhang, Yingjun Yan, Monica Red-Brewer, Siraj M Ali, Alexa B Schrock, Ahmet Zehir, Marc Ladanyi, Adam W Smith*, Jens Meiler*, Christine M Lovly*
Nature Communications
2021
General-Purpose Structure-Based Drug Discovery Neural Network Score Functions with Human-Interpretable Pharmacophore Maps
Benjamin P. Brown*, Jeffrey Mendenhall, Alexander R. Geanes, Jens Meiler*
Journal of Chemical Information and Modeling
2021
On-target Resistance to the Mutant-Selective EGFR Inhibitor Osimertinib Can Develop in an Allele-Specific Manner Dependent on the Original EGFR-Activating Mutation
Benjamin P. Brown, Yun-Kai Zhang, David Westover, Yingjun Yan, Huan Qiao, Vincent Huang, Zhenfang Du, Jarrod A Smith, Jeffrey S Ross, Vincent A Miller, Siraj Ali, Lyudmila Bazhenova, Alexa B Schrock, Jens Meiler*, Christine M Lovly*
Clinical Cancer Research
2019
BCL:: MolAlign: three-dimensional small molecule alignment for pharmacophore mapping
Benjamin P. Brown, Jeffrey Mendenhall, Jens Meiler*
Journal of Chemical Information and Modeling
2019